Safety Note from Tech Services Veterinarian Dr. Tammi Epp DVM, PhD, DACVSMR
When utilizing amnion-based technology to support the body’s endogenous capability to heal injuries, it is crucial to avoid NSAIDs and other anti-inflammatory nutraceuticals (including some herbs, general anti-inflammatory supplements, and CBD products). These substances may inhibit the essential biological processes that drive natural healing and regeneration, directly interfering with the efficacy of amnion-based products. Prostaglandin E2 (PGE2), a key mediator in healing, plays a pivotal role in orchestrating and modulating inflammation and its resolution, guiding macrophage polarization toward a regenerative phenotype, promoting angiogenesis, recruiting and activating stem cells, optimizing extracellular matrix deposition, and influencing the remodeling process. Suppressing PGE2 and related pathways with anti-inflammatory agents can disrupt these finely tuned processes, reverse regenerative bioscaffold-mediated signaling, and derail healing pathways. This interference alters the microenvironment, cellular players, and molecular mechanisms critical for repair, ultimately impairing accelerated healing. For optimal results and long-term success when utilizing amnion bioscaffold for various applications, preserving the body’s natural repair mechanisms is essential, as they work synergistically with the regenerative properties of amnion-based technology.
